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Study of enrichment factors for six β‐blockers in aliphatic alcohols by hollow‐fiber liquid‐phase microextraction
Author(s) -
Li QingLian,
Jing ShaoJun,
Zhang JinFeng,
Zhang Lin,
Ran CongCong,
Du ChaoHui,
Jiang Ye
Publication year - 2015
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201500487
Subject(s) - partition coefficient , solvent , chromatography , extraction (chemistry) , chemistry , octanol , liquid–liquid extraction , solubility , analyte , analytical chemistry (journal) , organic chemistry
The selectivity of a suitable organic solvent is key for extraction in liquid‐phase microextraction experiments. Nevertheless, the screening process remains a daunting task. Our research aimed to study the relationship between extraction efficiency and extraction solvents, analytes, and finally select the appropriate extraction solvent. In the present article, β‐blockers and six extraction solvents were chosen as the models and hollow‐fiber liquid‐phase microextraction was conducted. The relationship was built by statistical analysis on the data. Factors affecting extraction efficiency including the logarithms of the octanol/water partition coefficient (log P o/w ) of analytes, acid dissociation constants, the logarithms of the octanol/water partition coefficient of solvents and pH of the sample solution were investigated. The results showed that a low water solubility of extraction solvent is the foundation to ensure higher extraction efficiency. Moreover, when Δlog P o/w > 0, a higher extraction efficiency is observed at lower Δlog P o/w , on the contrary, when Δlog P o/w < 0, extraction efficiency is higher as the absolute value of Δlog P o/w becomes greater. Finally, the relationship between enrichment factor and extraction solvents, analytes was established and a helpful guidance was provided for the selection of an optimal solvent to obtain the best extraction efficiency by liquid‐phase microextraction.