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Dispersive solid–liquid phase microextraction based on nanomagnetic Preyssler heteropolyacid: A novel method for the preconcentration of nortriptyline
Author(s) -
Es'haghi Zarrin,
Hooshmand Sara
Publication year - 2015
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201401487
Subject(s) - detection limit , chromatography , solvent , disperser , sorbent , elution , extraction (chemistry) , aqueous solution , chemistry , analyte , adsorption , desorption , methanol , materials science , organic chemistry , composite material
In this study, a new, simple, rapid, and efficient method combined with ultraviolet visible spectrophotometry and high‐performance liquid chromatography analysis was developed for the extraction and determination of nortriptyline. The tendency of the Preyssler tungsten heteropolyacid, H 14 [NaP 5 W 30 O 110 ], immobilized on the surface of mesoporous nanomagnetite to adsorb the drug from the solution has been investigated. This method involves the use of an appropriate mixture of nanosorbent that was homogenized in disperser solvent (1.0 mL, ethanol). At first, the mixture containing the nanomagnetic sorbent and disperser solvent was injected into the aqueous sample, and a cloudy solution was formed. Subsequently, separation of the two phases was carried out using a magnet. In the second stage, analyte was desorbed from the sorbent by methanol as the optimal desorption solvent using sonication method. The elution solvent containing enriched analyte was introduced to the instruments for further analysis. Optimization of experimental conditions with respect to the extraction efficiency was investigated. The method was linear in the range of 25–5000, while the detection limit (LOD = 3 S B / m ) was 7.9 ng/mL and the limit of quantification (LOQ = 10 S B / m ) was 26.4 ng/mL. The relative standard deviation was 4.66%. The method was successfully applied to human hair samples.