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Homochiral metal–organic framework used as a stationary phase for high‐performance liquid chromatography
Author(s) -
Kong Jiao,
Zhang Mei,
Duan AiHong,
Zhang JunHui,
Yang Rui,
Yuan LiMing
Publication year - 2015
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201401034
Subject(s) - metal organic framework , high performance liquid chromatography , selectivity , phase (matter) , chromatography , chiral column chromatography , chemistry , metal , chiral stationary phase , porosity , stationary phase , column chromatography , chromatography column , analytical chemistry (journal) , organic chemistry , catalysis , adsorption
Metal–organic frameworks are promising porous materials. Chiral metal–organic frameworks have attracted considerable attention in controlling enantioselectivity. In this study, a homochiral metal–organic framework [Co 2 (D‐cam) 2 (TMDPy)] (D‐cam = d ‐camphorates, TMDPy = 4,4′‐trimethylenedipyridine) with a non‐interpenetrating primitive cubic net has been used as a chiral stationary phase in high‐performance liquid chromatography. It has allowed the successful separation of six positional isomers and six chiral compounds. The good selectivity and baseline separation, or at least 60% valley separation, confirmed its excellent molecular recognition characteristics. The relative standard deviations for the retention time of run‐to‐run and column‐to‐column were less than 1.8 and 3.1%, respectively. These results demonstrate that [Co 2 (D‐cam) 2 (TMDPy)] may represent a promising chiral stationary phase for use in high‐performance liquid chromatography.