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Study on clarithromycin lactobionate based dual selector systems for the enantioseparation of basic drugs in capillary electrophoresis
Author(s) -
Yu Tao,
Du Yingxiang,
Chen Jiaquan,
Xu Guangfu,
Yang Ke,
Zhang Qi,
Zhang Jinjing,
Du Shuaijing,
Feng Zijie,
Zhang Yanjie
Publication year - 2015
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201400677
Subject(s) - capillary electrophoresis , chemistry , cyclodextrin , chromatography , esmolol , clarithromycin , enantiomer , neomycin , pharmacology , antibiotics , organic chemistry , medicine , biochemistry , heart rate , blood pressure , radiology
In this paper, the use of clarithromycin lactobionate, a kind of antibiotic chiral selector, in combination with four neutral cyclodextrin derivatives (glucose‐β‐cyclodextrin, hydroxyethyl‐β‐cyclodextrin, methyl‐β‐cyclodextrin and hydroxypropyl‐β‐cyclodextrin) was reported for the first time. As a result, these dual systems gave much better resolution of nefopam (the Rs increased to 3.58, 2.72, 1.49 and 1.42, respectively) compared to the single systems. The effects of buffer pH and selector concentration on the separation of nefopam were also investigated. Additionally, some other basic drugs including metoprolol, atenolol, propranolol, bisoprolol, esmolol and ritodrine were tested for the investigation and evaluation of the enantiorecognition capability of the four dual systems. As expected, the synergistic effect was observed in four systems. Different results of these dual systems were also summarized.