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Extraction of methocarbamol from human plasma with a polypyrrole/multiwalled carbon nanotubes composite decorated with magnetic nanoparticles as an adsorbent followed by electrospray ionization ion mobility spectrometry detection †
Author(s) -
Saraji Mohammad,
Khayamian Taghi,
Hashemian Zahra
Publication year - 2014
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201400614
Subject(s) - materials science , detection limit , sorbent , polypyrrole , ion mobility spectrometry , extraction (chemistry) , electrospray ionization , mass spectrometry , nanoparticle , analytical chemistry (journal) , adsorption , chromatography , chemistry , nanotechnology , polymer , organic chemistry , composite material , polymerization
In this work, a polypyrrole/multiwalled carbon nanotubes composite decorated with Fe 3 O 4 nanoparticles was chemically synthesized and applied as a novel adsorbent for the extraction of methocarbamol from human plasma. Electrospray ionization ion mobility spectrometry was used for the determination of the analyte. The properties of the magnetic‐modified adsorbent were characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform IR spectroscopy, and X‐ray diffraction. The effects of experimental parameters on the extraction efficiency of the sorbent were investigated. Under the optimized conditions, the linear dynamic range was found to be 2–150 ng/mL with the detection limit of 0.9 ng/mL. The relative standard deviation was 5.3% for three replicate measurements of methocarbamol in plasma sample. The extraction efficiency of the sorbent for the determination of different drugs with various polarities was also compared to that of Fe 3 O 4 ‐polypyrrole and Fe 3 O 4 ‐multiwalled carbon nanotubes sorbents. Finally, the method was used for the determination of methocarbamol in blood samples.