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Experimental evaluation of the effect of a modified port‐location mode on the performance of a three‐zone simulated moving‐bed process for the separation of valine and isoleucine
Author(s) -
Park Chanhun,
Nam HeeGeun,
Kim PungHo,
Mun Sungyong
Publication year - 2014
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201400089
Subject(s) - valine , isoleucine , chemistry , chromatography , throughput , simulated moving bed , computer science , leucine , amino acid , organic chemistry , biochemistry , telecommunications , wireless , adsorption
The removal of isoleucine from valine has been a key issue in the stage of valine crystallization, which is the final step in the valine production process in industry. To address this issue, a three‐zone simulated moving‐bed (SMB) process for the separation of valine and isoleucine has been developed previously. However, the previous process, which was based on a classical port‐location mode, had some limitations in throughput and valine product concentration. In this study, a three‐zone SMB process based on a modified port‐location mode was applied to the separation of valine and isoleucine for the purpose of making a marked improvement in throughput and valine product concentration. Computer simulations and a lab‐scale process experiment showed that the modified three‐zone SMB for valine separation led to >65% higher throughput and >160% higher valine concentration compared to the previous three‐zone SMB for the same separation.