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Premium Silver‐coated monolithic columns for separation in radiopharmaceutical applications
Author(s)
Sedlacek Ondrej,
Kucka Jan,
Svec Frantisek,
Hruby Martin
Publication year2014
Publication title
journal of separation science
Resource typeJournals
PublisherWiley-Blackwell
In this study, we demonstrate the preparation of a macroporous monolithic column containing anchored silver nanoparticles and its use for the elimination of excess radioiodine from the radiolabeled pharmaceutical. The poly(glycidyl methacrylate‐co‐ethylene dimethacrylate) monolith was first functionalized with cystamine and the free thiol groups liberated by reaction with borohydride. In‐house‐prepared silver nanoparticles were then attached by interaction with the surface thiols. The deiodization process was demonstrated with the commonly used radiopharmaceutical m ‐iodobenzylguanidine labeled with radionuclide iodine‐125.
Subject(s)biochemistry , borohydride , catalysis , chemistry , cystamine , glycidyl methacrylate , materials science , methacrylate , monolith , nanoparticle , nanotechnology , nuclear chemistry , organic chemistry , polymer , polymerization , radiochemistry , silver nanoparticle
Language(s)English
SCImago Journal Rank0.72
H-Index102
eISSN1615-9314
pISSN1615-9306
DOI10.1002/jssc.201301325

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