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Silver‐coated monolithic columns for separation in radiopharmaceutical applications
Author(s) -
Sedlacek Ondrej,
Kucka Jan,
Svec Frantisek,
Hruby Martin
Publication year - 2014
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201301325
Subject(s) - cystamine , glycidyl methacrylate , monolith , methacrylate , chemistry , silver nanoparticle , borohydride , nanoparticle , radiochemistry , nuclear chemistry , materials science , nanotechnology , organic chemistry , polymerization , catalysis , polymer , biochemistry
In this study, we demonstrate the preparation of a macroporous monolithic column containing anchored silver nanoparticles and its use for the elimination of excess radioiodine from the radiolabeled pharmaceutical. The poly(glycidyl methacrylate‐co‐ethylene dimethacrylate) monolith was first functionalized with cystamine and the free thiol groups liberated by reaction with borohydride. In‐house‐prepared silver nanoparticles were then attached by interaction with the surface thiols. The deiodization process was demonstrated with the commonly used radiopharmaceutical m ‐iodobenzylguanidine labeled with radionuclide iodine‐125.