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Challenges and strategies in the preparation of large‐volume polymer‐based monolithic chromatography adsorbents
Author(s) -
Ongkudon Clarence M.,
Kansil Tamar,
Wong Charlotte
Publication year - 2014
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201300995
Subject(s) - monolith , materials science , polymer , volume (thermodynamics) , molecularly imprinted polymer , chromatography , adsorption , porosity , nanotechnology , chemistry , composite material , selectivity , physics , organic chemistry , quantum mechanics , catalysis , biochemistry
To date, the number of published reports on the large‐volume preparation of polymer‐based monolithic chromatography adsorbents is still lacking and is of great importance. Many critical factors need to be considered when manufacturing a large‐volume polymer‐based monolith for chromatographic applications. Structural integrity, validity, and repeatability are thought to be the key factors determining the usability of a large‐volume monolith in a separation process. In this review, we focus on problems and solutions pertaining to heat dissipation, pore size distribution, “wall channel” effect, and mechanical strength in monolith preparation. A template‐based method comprising sacrificial and nonsacrificial techniques is possibly the method of choice due to its precise control over the porous structure. However, additional expensive steps are usually required for the template removal. Other strategies in monolith preparation are also discussed.