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Response surface methodology applied to SPE for the determination of ibuprofen in various types of water samples
Author(s) -
Paíga Paula,
DelerueMatos Cristina
Publication year - 2013
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201300544
Subject(s) - ibuprofen , chromatography , chemistry , response surface methodology , solid phase extraction , extraction (chemistry) , volume (thermodynamics) , sample preparation , surface water , selectivity , analytical chemistry (journal) , environmental science , environmental engineering , biochemistry , pharmacology , quantum mechanics , catalysis , medicine , physics
Over the last few years, there has been a growing concern about the presence of pharmaceuticals in the environment. The main objective of this study was to develop and validate an SPE method using surface response methodology for the determination of ibuprofen in different types of water samples. The influence of sample pH and sample volume on the ibuprofen recovery was studied. The effect of each studied independent variable is pronounced on the dependent variable (ibuprofen recovery). Good selectivity, extraction efficiency, and precision were achieved using 600 mL of sample volume with the pH adjusted to 2.2. LC with fluorescence detection was employed. The optimized method was applied to 20 water samples from the N orth and S outh of P ortugal.