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Simultaneous derivatization and air‐assisted liquid–liquid microextraction of some parabens in personal care products and their determination by GC with flame ionization detection
Author(s) -
Farajzadeh Mir Ali,
Khosrowshahi Elnaz Marzi,
Khorram Parisa
Publication year - 2013
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201300436
Subject(s) - derivatization , chromatography , extraction (chemistry) , chemistry , detection limit , flame ionization detector , solvent , sample preparation , aqueous solution , analyte , gas chromatography , ionic liquid , high performance liquid chromatography , organic chemistry , catalysis
A simultaneous derivatization/air‐assisted liquid–liquid microextraction technique has been developed for the sample pretreatment of some parabens in aqueous samples. The analytes were derivatized and extracted simultaneously by a fast reaction/extraction with butylchloroformate (derivatization agent/extraction solvent) from the aqueous samples and then analyzed by GC with flame ionization detection. The effect of catalyst type and volume, derivatization agent/extraction solvent volume, ionic strength of aqueous solution, pH, numbers of extraction, aqueous sample volume, etc. on the method efficiency was investigated. Calibration graphs were linear in the range of 2–5000 μg/L with squared correlation coefficients >0.990. Enhancement factors and enrichment factors ranged from 1535 to 1941 and 268 to 343, respectively. Detection limits were obtained in the range of 0.41–0.62 μg/L. The RSD s for the extraction and determination of 250 μg/L of each paraben were <4.9% ( n = 6). In this method, the derivatization agent and extraction solvent were the same and there is no need for a dispersive solvent, which is common in a traditional dispersive liquid–liquid microextraction technique. Furthermore, the sample preparation time is very short.