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New analytical method for the determination of musks in personal care products by Q uick, E asy, C heap, E ffective, R ugged, and S afe extraction followed by GC – MS
Author(s) -
Homem Vera,
Avelino Silva José,
Cunha Carina,
Alves Arminda,
Santos Lúcia
Publication year - 2013
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201300190
Subject(s) - quechers , chemistry , chromatography , extraction (chemistry) , anhydrous , solvent , organic chemistry , pesticide residue , pesticide , agronomy , biology
Synthetic musks are organic compounds used as fragrance additives and fixative compounds in a diversity of personal care products. A new method based on quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction followed by GC – MS for the analysis of 12 musks in personal care products was developed and validated. Some experimental parameters, such as total Q u EC h ERS mass, sample mass/solvent volume ratio, type of extraction solvent, as well as salts and sorbents amount were investigated and optimized. The final method involves the musks extraction using acetonitrile, followed by the addition of anhydrous magnesium sulphate and sodium acetate. The clean‐up step was performed using dispersive SPE with primary and secondary amine and octadecyl–silica sorbents. This extraction procedure is fast (about 10 min) when compared to other traditional approaches. The method was robust for the matrices studied and shows a high precision (%RSD < 15%) and accuracy (average recovery of 85%), allowing the detection of musks in minimum concentrations between 0.01 ng/g (galaxolide) and 15.80 ng/g (musk xylene). The developed method was applied to the analysis of 12 samples, which revealed musks concentrations ranging from 2 ng/g (toothpaste) to 882 340 ng/g (perfumed body lotion).