Premium
Polymer monolithic capillary microextraction combined on‐line with inductively coupled plasma MS for the determination of trace rare earth elements in biological samples
Author(s) -
Zhang Lin,
Chen Beibei,
He Man,
Hu Bin
Publication year - 2013
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201300100
Subject(s) - iminodiacetic acid , chemistry , inductively coupled plasma , chromatography , inductively coupled plasma mass spectrometry , detection limit , capillary action , sample preparation , extraction (chemistry) , inductively coupled plasma atomic emission spectroscopy , analytical chemistry (journal) , methacrylate , glycidyl methacrylate , polymer , mass spectrometry , materials science , chelation , plasma , polymerization , inorganic chemistry , physics , organic chemistry , quantum mechanics , composite material
A rapid and sensitive method based on polymer monolithic capillary microextraction combined on‐line with microconcentric nebulization inductively coupled plasma MS has been developed for the determination of trace/ultratrace rare earth elements in biological samples. For this purpose, the iminodiacetic acid modified poly(glycidyl methacrylate‐trimethylolpropane trimethacrylate) monolithic capillary was prepared and characterized by SEM and FTIR spectroscopy. Factors affecting the extraction efficiency, such as sample pH, sample flow rate, sample/eluent volume, and coexisting ions were investigated in detail. Under the optimal conditions, the LOD s for rare earth elements were in the range of 0.08 ( E r) to 0.97 ng/L ( N d) with a sampling frequency of 8.5 h −1 , and the RSD s were between 1.5% ( S m) and 7.4% ( N d) (c = 20 ng/L, n = 7). The proposed method was successfully applied to the analysis of trace/ultratrace rare earth elements in human urine and serum samples, and the recoveries for the spiked samples were in the range of 82–105%. The developed method was simple, rapid, sensitive, and favorable for the analysis of trace/ultratrace rare earth elements in biological samples with limited sample volume.