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Electro‐assisted solid‐phase microextraction based on poly(3,4‐ethylenedioxythiophen) combined with GC for the quantification of tricyclic antidepressants
Author(s) -
Hosseiny Davarani Saied Saeed,
Nojavan Saeed,
Asadi Roghayeh,
Banitaba Mohammad Hossein
Publication year - 2013
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201300099
Subject(s) - solid phase microextraction , chromatography , detection limit , calibration curve , extraction (chemistry) , flame ionization detector , chemistry , analytical chemistry (journal) , solid phase extraction , materials science , fiber , gas chromatography , mass spectrometry , gas chromatography–mass spectrometry , organic chemistry
In this study, a platinum wire coated with poly(3,4‐ethylenedioxythiophen) was used as an electro‐assisted solid‐phase microextraction fiber for the quantification of tricyclic antidepressant drugs in biological samples by coupling to GC employing a flame ionization detector. In this study, an electric field increased the extraction rate and recovery. The fiber used as a solid phase was synthesized by the electropolymerization of 3,4‐ethylenedioxythiophen monomers onto a platinum wire. The ability of this fiber to extract imipramine, desipramine, and clomipramine by using the electro‐assisted solid‐phase microextraction technique was evaluated. The effect of various parameters that influence the extraction efficiency, which include solution temperature, extraction time, stirring rate, ionic strength, time and temperature of desorption, and thickness of the fiber, was optimized. Under optimized conditions, the linear ranges and regression coefficients of calibration curves were in the range of 0.5–250 and 0.990–0.998 ng/mL, respectively. Detection limits were in the range of 0.15–0.45 ng/mL. Finally, this method was applied to the determination of drugs in urine and wastewater samples and recoveries were 4.8–108.9%.