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A simplified approach to direct solid‐phase extraction: mass spectrometry
Author(s) -
Candish Esme,
Gooley Andrew,
Wirth HansJürgen,
Dawes Peter A.,
Shellie Robert A.,
Hilder Emily F.
Publication year - 2012
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201270141
Subject(s) - cartridge , workflow , chromatography , sorbent , sample preparation , solid phase extraction , mass spectrometry , sample (material) , extraction (chemistry) , computer science , process engineering , chemistry , materials science , analytical chemistry (journal) , engineering , database , organic chemistry , adsorption , metallurgy
DOI: 10.1002/jssc.201200466 A hand held digital format of the microextraction by packed sorbent technique (MEPS) has been integrated into the ESI‐MS workflow for the rapid screening of drugmetabolites in urine. This at‐line approach to sample preparation couples rapid workflows with direct analysis enabling the entire analytical workflow to be achieved in a few minutes. A novel format of MEPS has been introduced which incorporates a two‐way valve between the MEPS cartridge and the syringe barrel enabling the direction of the flow to be controlled. By controlling the direction of the flow, sharp concentrated sample bands can be introduced directly into the MS in small volumes.