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Hydrodynamic chromatography separations in micro‐ and nanopillar arrays produced using deep‐ UV lithography (J. Sep. Science 35'15)
Author(s) -
Op de Beeck Jeff,
De Malsche Wim,
De Moor Piet,
Desmet Gert
Publication year - 2012
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201270111
Subject(s) - nanopillar , polystyrene , pillar , fluorescence , lithography , materials science , chromatography , analytical chemistry (journal) , nanotechnology , soft lithography , fluorescein , chemistry , nanostructure , optoelectronics , optics , polymer , fabrication , composite material , medicine , physics , alternative medicine , structural engineering , pathology , engineering
DOI: 10.1002/jssc.201200076 Micro‐pillar array columns with an inter‐pillar spacing down to 500 nm have been designed and fabricated enabling hydrodynamic chromatography separations of fluorescently labeled polystyrene nano‐particles. Injecting sub‐nanoliter sized sample volumes and detecting the fluorescent signal on‐chip, fluorescein, 20 and 40 nm diameter particles could be separated in less than 1.5 minutes