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Rapid screening and determination of designer drugs in saliva by a nib‐assisted paper spray‐mass spectrometry and separation technique
Author(s) -
Lee Hsun,
Jhang ChihSheng,
Liu JuTsung,
Lin ChengHuang
Publication year - 2012
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201200480
Subject(s) - chromatography , mass spectrometry , chemistry , capillary electrophoresis–mass spectrometry , electrospray , detection limit , electrospray ionization , analytical chemistry (journal) , desorption electrospray ionization , desorption , capillary electrophoresis , ionization , chemical ionization , organic chemistry , ion , adsorption
A method for the rapid screening and determination of amphetamine‐type designer drugs in saliva by a novel nib‐assisted paper spray‐mass spectrometry procedure is described. Under optimized conditions, the limit of detections for amphetamine derivatives (model samples: o‐ , m‐ , p‐ chloroamphetamine and o‐ , m‐ , p‐ fluoroamphetamine, respectively) were determined to 0.1 μg/mL by the nib‐assisted paper spray‐mass spectrometry method. This method is easier and has a higher sensitivity than similar methodologies, including atmospheric pressure/matrix‐assisted laser desorption ionization mass spectrometry and electrospray‐assisted laser desorption ionization/mass spectrometry. Data obtained using more classical separation methods, including liquid chromatography and capillary electrophoresis, are also reported.