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Extraction and determination of hormones in cosmetics by homogeneous ionic liquid microextraction high‐performance liquid chromatography
Author(s) -
Kang Mingqin,
Sun Shuo,
Li Na,
Zhang Daihui,
Chen Mingyan,
Zhang Hanqi
Publication year - 2012
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201200206
Subject(s) - ionic liquid , hexafluorophosphate , chromatography , chemistry , extraction (chemistry) , tetrafluoroborate , high performance liquid chromatography , detection limit , solvent , organic chemistry , catalysis
The homogeneous ionic liquid microextraction was applied to the extraction of hormones from cosmetics and the hormones were determined by high‐performance liquid chromatography. 1‐Hexyl‐3‐methylimidazolium tetrafluoroborate was used as extraction solvent. Ammonium hexafluorophosphate as used as ion‐pairing agent. Several experimental parameters, including the volume of 1‐hexyl‐3‐methylimidazolium tetrafluoroborate, amount of ammonium hexafluorophosphate and sodium chloride, extraction and centrifuge time, and the pH value, were optimized. The limits of detection and quantification for the analytes ranged from 0.03 to 0.24 ng/mL and from 0.10 to 0.79 ng/mL, respectively. The precision for determining the hormones was lower than 5.2%. The proposed method was successfully developed for the determination of hormones in real cosmetic samples.