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Chiral separation using capillary electromigration techniques based on ligand exchange principle
Author(s) -
Zhang Haizhi,
Qi Li,
Mao Lanqun,
Chen Yi
Publication year - 2012
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201200067
Subject(s) - capillary electrochromatography , capillary electrophoresis , electromigration , micellar electrokinetic chromatography , chemistry , capillary action , electrokinetic phenomena , chromatography , micelle , electrochromatography , analytical chemistry (journal) , materials science , organic chemistry , aqueous solution , composite material
Over the last couple of decades, researchers have developed diverse chiral separation methods emerged from a few chiral separation principles. This review article is primarily focused on the application of chiral ligand‐exchange ( CLE ) principle in capillary electromigration techniques, such as capillary electrophoresis ( CE ) and capillary electrochromatography ( CEC ). First, the most commonly used CLE‐CZE separation mode by using different kinds of central ions, such as C u(II), Z n(II), borate ion, and other metal ions, has been introduced. Meanwhile, several kinds of surfactants have been applied as the micelle‐forming agents in the CLE micellar electrokinetic chromatography mode. The highlight of recent research of CLE‐CEC is the exploitation of novel columns for chiral separation. Then, two kinds of capillary columns, packed capillary and monolithic capillary column, have been briefly described. Finally, the effective application of these chiral separation methods has been presented, including the application in life science and food analysis area.