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Separation methods for captopril in pharmaceuticals and biological fluids
Author(s) -
Mansour Fotouh R.,
Danielson Neil D.
Publication year - 2012
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201200057
Subject(s) - captopril , capillary electrophoresis , chemistry , chromatography , biological fluids , high performance liquid chromatography , angiotensin converting enzyme , medicine , blood pressure , radiology
Captopril ( CAP ) is an orally active angiotensin‐converting enzyme ( ACE ) inhibitor and has been widely used for management of hypertension and congestive heart failure. CAP lacks an aromatic chromophore required for facile direct UV detection and also has two chiral centers. These factors can render the determination of CAP in complex matrices challenging. This review covers more than 20 years of analytical research on this drug, focusing mainly on pharmaceutical and biological applications. The primary separation techniques discussed are gas chromatography, liquid chromatography, and capillary electrophoresis. The structures of the CAP derivatizing agents as well as a table summarizing various HPLC methods are provided. A discussion of key recent chromatographic and electrophoretic methods for other ACE inhibitors is also present.