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Monolithic columns with optimized pore structure for molecular size‐based separations of synthetic polymers
Author(s) -
Korolev Alexander,
Victorova Elena,
Ibragimov Timur,
Kanatyeva Anastasiya,
Kurganov Alexander
Publication year - 2012
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201101042
Subject(s) - polystyrene , molar mass , polymer , monolithic hplc column , toluene , materials science , divinylbenzene , chromatography , solvent , chemistry , copolymer , high performance liquid chromatography , organic chemistry , styrene , composite material
Monolithic capillary columns based on divinylbenzene were synthesized using different alcanols as porogens. Prepared columns were tested in separation of polystyrene standards according to their molar mass ( MM ) and were characterized by corresponding calibration graphs. It was demonstrated that a decrease of alcanol chain length from dodecanol to octanol resulted in a decrease of column permeability and in an improved column ability to separate polystyrene standards. In contrast, removing a good solvent from porogen mixture results in an increase of column permeability and in a decrease of column performance toward polystyrene standards. Optimized synthetic conditions included porogen composed of nonanol and toluene or mesytilene, and the column prepared with this porogen was capable of separating a mixture of 14 polystyrene standards with MM ranged from several millions to oligomers.