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Magnetic solid‐phase extraction using magnetic hypercrosslinked polymer for rapid determination of illegal drugs in urine
Author(s) -
Gao Qiang,
Lin CaiYong,
Luo Dan,
Suo LiLi,
Chen JianLi,
Feng YuQi
Publication year - 2011
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201100634
Subject(s) - divinylbenzene , detection limit , solid phase extraction , chemistry , extraction (chemistry) , chromatography , sorbent , adsorption , fourier transform infrared spectroscopy , methacrylic acid , precipitation polymerization , polymerization , polymer , nuclear chemistry , copolymer , styrene , chemical engineering , radical polymerization , organic chemistry , engineering
A novel magnetic material Fe 3 O 4 /SiO 2 /P(MAA‐ co ‐VBC‐ co ‐DVB) was prepared via the hypercrosslinking of its precursor which was produced via precipitation polymerization of methacrylic acid (MAA), vinylbenzyl chloride (VBC), and divinylbenzene (DVB) in the presence of Fe 3 O 4 /SiO 2 submicrospheres with the surface containing abundant reactive double bonds. The resultant sorbent was characterized by scan electron microscopy, N 2 adsorption, and Fourier transform infrared spectroscopy. It was found that this material had remarkable features such as large surface area (500 m 2 /g) and pore volume (0.32 cm 3 /g), as well as desirable chemical composition (including hydrophobic and ion‐exchange moieties). Taking advantages of the Fe 3 O 4 /SiO 2 /P(MAA‐ co ‐VBC‐ co ‐DVB), a magnetic SPE (MSPE) coupled with capillary electrophoresis (CE) method was developed for the determination of illegal drugs in urine samples. The extraction time could be clearly shortened up to 3 min. The recoveries of these drug compounds were in the range of 84.0–123% with relative standard deviations ranging between 1.7 and 10.5%; the limit of detection was in the range of 4.0–6.0 μg/L. The proposed method is simple, effective, and low‐cost, and provides an accurate and sensitive detection platform for abused drug analysis.