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High‐sensitivity capillary and microchip electrophoresis using electrokinetic supercharging
Author(s) -
Dawod Mohamed,
Chung Doo Soo
Publication year - 2011
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201100384
Subject(s) - isotachophoresis , capillary electrophoresis , electrokinetic phenomena , analyte , chromatography , chemistry , sensitivity (control systems) , analytical chemistry (journal) , electrolyte , engineering , electrode , electronic engineering
Electrokinetic supercharging (EKS) is considered as one of the most powerful online preconcentration techniques in electrophoresis. It combines the efficient preconcentration power of field‐amplified sample injection and the exceptional selective nature of transient isotachophoresis. It has a wide range of applications to different types of analytes ranging from small ions to large proteins and DNA fragments. This comprehensive review — up to date — provides listing for all the works, developments, and advances in EKS. The review will pay particular attention to innovations, new methodologies for manipulation, challenges for improving the detection sensitivity, and various applications of EKS in capillaries and microchips.