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Magnetic solid‐phase extraction based on magnetic carbon nanotube for the determination of estrogens in milk
Author(s) -
Ding Jun,
Gao Qiang,
Li XiaoShui,
Huang Wei,
Shi ZhiGuo,
Feng YuQi
Publication year - 2011
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201100323
Subject(s) - carbon nanotube , magnetic nanoparticles , materials science , detection limit , graphene , extraction (chemistry) , solid phase extraction , solvent , nanomaterials , nanoparticle , chromatography , analytical chemistry (journal) , nanotechnology , chemical engineering , chemistry , organic chemistry , engineering
In this work, a novel method for the fabrication of magnetic carbon nanotubes based on ‘aggregation wrap’ was proposed. When carbon nanotubes and magnetic nanoparticles were vortically mixed in a solvent, the magnetic nanoparticles were wrapped into the carbon nanotube bundles that formed during the aggregation process, leading to the formation of magnetic carbon nanotubes. Thus, the resultant material can be separated from the solvent rapidly and conveniently by a magnet. Our investigation demonstrated that the ‘aggregation wrap’ mechanism for the preparation of magnetic composite is also applicable to other self‐aggregated micro/nanomaterials, including graphene, graphite, C 60 , etc. To testify the feasibility of the magnetic composites in sample preparation, the resultant magnetic carbon nanotubes were applied as sorbents for magnetic solid‐phase extraction (MSPE) of estrogens in milk samples. Under optimized conditions, a rapid, convenient and efficient method for the determination of estrogens in milk samples was established by the combination of MSPE with high‐performance liquid chromatography with fluorescence detector. The linearity range of the proposed method was 5–2000 μg/L with correlation coefficients ( R ) of 0.9983–0.9994. The limit of detection (LOD) for three estrogens ranged from 1.21 to 2.35 μg/L. The intra‐ and inter‐day relative standard deviations (RSDs) were <9.3%. The reproducibility of the MSPE with different batches of magnetic carbon nanotubes was acceptable with RSD values <3.6%.