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Performance evaluation of a rapid‐scanning quadrupole mass spectrometer in the comprehensive two‐dimensional gas chromatography analysis of pesticides in water
Author(s) -
Purcaro Giorgia,
Quinto Tranchida Peter,
Conte Lanfranco,
Obiedzińska Agnieszka,
Dugo Paola,
Dugo Giovanni,
Mondello Luigi
Publication year - 2011
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201100085
Subject(s) - chemistry , chromatography , detection limit , mass spectrometry , analytical chemistry (journal) , solid phase microextraction , gas chromatography , analyte , calibration , gas chromatography–mass spectrometry , calibration curve , quadrupole mass analyzer , physics , quantum mechanics
The performance of a novel rapid‐scanning (20 000 amu/s) quadrupole mass spectrometer (qMS) has been evaluated in the comprehensive 2‐D gas chromatography (GC×GC) analysis of pesticides contained in water. Analyte extraction was performed by using direct solid‐phase microextraction (SPME). The MS system was operated using a rather wide m/z 50–450 mass range and a 33 Hz spectral production rate, a frequency which was found sufficient for reliable quantification. The qMS performance was evaluated considering: (i) number of data points per peak, (ii) mass spectral quality, (iii) extent of peak skewing, and (iv) consistency of retention times. Seven‐point calibration curves (external calibration) were constructed for 28 pesticides over the limit of quantification range of 100 μg/L (1, 5, 10, 25, 50, and 100 μg/L). The solid‐phase microextraction‐GC×GC‐qMS method was validated by calculating limits of detection and quantification, intraday peak area precision, accuracy, and intraday retention‐time precision. A series of tap water samples were subjected to analysis, fortunately giving negative results.