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Separation of acetins by counter‐current chromatography
Author(s) -
Meireles Bruno Amaral,
Pinto Shaft Corrêa,
Pereira Vera Lúcia Patrocinio,
Leitão Gilda Guimarães
Publication year - 2011
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201000901
Subject(s) - countercurrent chromatography , triacetin , chromatography , chemistry , countercurrent exchange , separation process , ethyl acetate , solvent , butanol , column chromatography , organic chemistry , ethanol , physics , thermodynamics
In this work we report the purification of a crude acetin mixture into mono‐, di‐ and triacetin by countercurrent chromatography. The process was initially tested on a small, semi‐preparative scale (0.5 g) to determine its efficiency. The process was then scaled up to accommodate 2.5 g of crude reaction products containing a mixture of the acetins. The solvent system ethyl acetate/ n ‐butanol/water 1:0.2:1 was used in all separation procedures. Mono‐, di‐ and triacetins were separated similarly in the semi‐preparative and preparative runs.