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Preparation and chiral recognition in HPLC of cellulose 3,5‐dichlorophenylcarbamates immobilized onto silica gel
Author(s) -
Qu Haitao,
Li Junqing,
Wu Guangshun,
Shen Jun,
Shen Xiande,
Okamoto Yoshio
Publication year - 2011
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201000800
Subject(s) - cellulose , silica gel , tetrahydrofuran , high performance liquid chromatography , chemistry , chloroform , chromatography , condensation polymer , residue (chemistry) , organic chemistry , polymer chemistry , polymer , solvent
The 3,5‐dichlorophenylcarbamates ( 2 ) of cellulose bearing a small amount of 3‐(triethoxysilyl)propyl residues were synthesized by a one‐pot process and immobilized onto a silica gel through intermolecular polycondensation of the triethoxysilyl groups. The obtained cellulose derivatives were characterized by 1 H NMR and elemental analysis (EA), and their recognition abilities were evaluated by high‐performance liquid chromatography (HPLC). The cellulose derivatives containing about 1–5% of the 3‐(triethoxysilyl)propyl residue were efficiently immobilized with a high chiral recognition ability. The immobilized chiral packing materials (CPMs) could be used with the eluents containing chloroform and tetrahydrofuran (THF), which cannot be used with the conventional coated‐type chiral packing materials. By using these eluents, the chiral recognition for many racemates was improved.