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Determination of fluoroquinolones in blood by matrix solid‐phase dispersion extraction and CE
Author(s) -
Li Dan,
Yang Qiuling,
Wang Ziming,
Su Rui,
Xu Xu,
Zhang Hanqi
Publication year - 2011
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201000693
Subject(s) - chromatography , extraction (chemistry) , solid phase extraction , chemistry , dispersion (optics) , matrix (chemical analysis) , detection limit , physics , optics
A simple and rapid method for the determination of residues of four fluoroquinolones in blood samples was developed. The method was based on matrix solid‐phase dispersion extraction followed by CE with ultraviolet detection. 1‐Butyl‐3‐methylimidazolium tetrafluoroborate aqueous solution was used as the background electrolyte for the separation of fluoroquinolones. The average recoveries of the four fluoroquinolones at two spiked levels ranged from 54.0 to 86.4% for pig blood, and 45.4 to 79.9% for deer blood, with the relative standard deviations <9.45%. Detection limits for the four fluoroquinolones in blood sample ranged from 0.15 to 0.31 μg/mL.