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Liquid chromatography at critical conditions in ternary mobile phases: Gradient elution along the critical line
Author(s) -
Trathnigg Bernd,
Malik Muhammad Imran,
Pircher Nicole,
Hayden Stephan
Publication year - 2010
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201000181
Subject(s) - ethylene oxide , elution , ethylene glycol , propylene oxide , ternary operation , chromatography , copolymer , polypropylene , chemistry , oxide , methanol , phase (matter) , resolution (logic) , analytical chemistry (journal) , chemical engineering , materials science , organic chemistry , polymer , artificial intelligence , computer science , engineering , programming language
In ternary mobile phases consisting of acetone, methanol, and water, the retention of PEG on reversed‐phase columns is independent on molar mass at certain compositions of the mobile phase. Along this critical adsorption line, the retention of polypropylene glycol varies quite strongly, which can be utilized in the separation of block copolymers. Gradient elution along the critical line allows a baseline separation of all oligomers in polypropylene glycol up to approximately 25 propylene oxide units. The same resolution can be achieved in the separation of ethylene oxide‐propylene oxide block copolymers, regardless of the length of the ethylene oxide block.