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Capillary electrophoresis‐mass spectrometry for the analysis of amino acids
Author(s) -
Desiderio Claudia,
Iavarone Federica,
Rossetti Diana Valeria,
Messana Irene,
Castagnola Massimo
Publication year - 2010
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201000171
Subject(s) - chemistry , amino acid , capillary electrophoresis , mass spectrometry , sulfation , chromatography , amino acid analysis , enantiomer , capillary electrophoresis–mass spectrometry , biochemistry , electrospray ionization , organic chemistry
In this review, the recent contribution of CE‐MS technology to the analysis of amino acids, as well as the advantages of the hyphenation and the technologies involved in the instrumental coupling are reported. Different sections are dedicated to the recent contributions of CE‐MS to the analysis of protein amino acids and their post‐translational modifications, such as phosphorylation and sulfation. CE‐MS analysis of some amino acid derivatives, such as the free methylated‐derivatives of arginine is also discussed. A section is specifically devoted to the CE‐MS applications in the field of chiral separation of D ‐ and L ‐amino acid enantiomers.