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Ionic liquid‐based ultrasound‐assisted extraction of fangchinoline and tetrandrine from Stephaniae tetrandrae
Author(s) -
Zhang Lijin,
Geng Yanling,
Duan Wenjuan,
Wang Daijie,
Fu Maorun,
Wang Xiao
Publication year - 2009
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200900413
Subject(s) - tetrandrine , extraction (chemistry) , ionic liquid , chromatography , ultrasound , reproducibility , chemistry , medicine , pharmacology , organic chemistry , radiology , catalysis
Abstract An ionic liquid‐based ultrasound‐assisted extraction method has been developed for the effective extraction of fangchinoline and tetrandrine from Stephaniae tetrandrae . The effects of some ultrasound‐assisted extraction parameters including the concentration of [BMIM][BF 4 ], pH, ultrasonic power and time were investigated to optimize the ultrasound‐assisted extraction conditions. Compared to the regular ultrasound‐assisted extraction and traditional refluent extraction, the proposed [BMIM][BF 4 ]‐based ultrasound‐assisted extraction offered shorter extraction times (from 6 h to 40 min) and remarkable higher efficiencies (approximately 30% improved), which supported the suitability of the proposed approach. In addition, the proposed approach was confirmed by the good correlation coefficient ( R 2 ), recovery and reproducibility (RSD, n = 5), which were in the range of 0.9992–0.9995, 85.5–101.1%, and 1.87–4.33%, respectively.