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Ionic liquid surfactant‐mediated ultrasonic‐assisted extraction coupled to HPLC: Application to analysis of tanshinones in Salvia miltiorrhiza bunge
Author(s) -
Wu Kangkang,
Zhang Qianli,
Liu Qian,
Tang Fei,
Long Yiming,
Yao Shouzhuo
Publication year - 2009
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200900398
Subject(s) - salvia miltiorrhiza , extraction (chemistry) , ionic liquid , chromatography , chemistry , high performance liquid chromatography , aqueous solution , solvent , pulmonary surfactant , micelle , organic chemistry , medicine , biochemistry , alternative medicine , pathology , traditional chinese medicine , catalysis
Abstract Ionic liquid surfactants are a class of ionic liquids (ILs), which can form micelles in the aqueous solution. In this paper, we demonstrate a novel extracting system based on the use of IL surfactants in ultrasonic‐assisted extraction followed by HPLC analysis. No organic solvents were used in the extraction, making this method environmentally friendly and more attractive than the conventional organic solvent‐based extraction methods. As an example, this method was applied to determine tanshinones in Chinese herbal medicine Salvia miltiorrhiza bunge . The effect of the carbon chain length of the IL cation, as well as other influencing factors on ultrasonic‐assisted extraction, was investigated in detail. Under the optimized conditions, satisfactory extraction efficiency was achieved with the recoveries ranging from 87.5 to 107.6%, and the RSDs were lower than 6%. This work shows a promising prospect of the IL surfactants in the extraction of active ingredients from herbs.