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The lipophilicity of parabens estimated on reverse phases chemically bonded and oil‐impregnated plates and calculated using different computation methods
Author(s) -
Casoni Dorina,
Sârbu Costel
Publication year - 2009
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200900037
Subject(s) - lipophilicity , chemistry , chromatography , principal component analysis , methanol , sunflower oil , silica gel , analytical chemistry (journal) , organic chemistry , mathematics , statistics , biochemistry
The chromatographic behaviour of the parabens has been investigated on RP‐18F 254S , RP‐18WF 254S , CNF 254S , Diol F 254s and silica gel 60F 254 plates impregnated with different oils (paraffin, olive, sunflower and corn) using methanol–water mixtures in different volume proportions as mobile phases, the regression determination coefficients being excellent (higher than 0.98 for the majority of compounds). Moreover, highly significant correlations were obtained between different experimental indices of lipophilicity ( R M0 , b and scores corresponding to the first principal component (PC1)) and computed log P values. All types of stationary phases investigated appear to be highly suited for estimating the lipophilicity of the parabens.