Molecularly imprinted polymer for solid‐phase extraction of ephedrine and analogs from human plasma | Zendy

Lasáková Martina | Zendy; Thiébaut Didier | Zendy; Jandera Pavel | Zendy; Pichon Valérie | Zendy

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Molecularly imprinted polymer for solid‐phase extraction of ephedrine and analogs from human plasma

Author(s) -

Lasáková Martina,

Thiébaut Didier,

Jandera Pavel,

Pichon Valérie

Publication year - 2009

Publication title -

journal of separation science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.72

H-Index - 102

eISSN - 1615-9314

pISSN - 1615-9306

DOI - 10.1002/jssc.200800684

Subject(s) - molecularly imprinted polymer , ephedrine , chemistry , nip , chromatography , extraction (chemistry) , methacrylic acid , solid phase extraction , molecular imprinting , alkaloid , polymer , human plasma , monomer , selectivity , organic chemistry , materials science , pharmacology , composite material , catalysis , medicine

A molecularly imprinted polymer (MIP) was synthesized and evaluated to selectively extract ephedrine from human plasma. The MIP synthesis was performed in chloroform with methacrylic acid as a functional monomer and the target alkaloid as a template molecule. The resulting MIP was applied to the selective extraction of ephedrine from a pure aqueous medium. A recovery about 74% was obtained using the MIP with only 7% on the nonimprinted polymer (NIP). A very straightforward selective SPE procedure was then successfully applied to the direct extraction of ephedrine from spiked human plasma with a high extraction recovery (68%) on the MIP with no recovery on the NIP. Moreover, the MIP was used for the selective extraction of catecholamine neurotransmitters, i.e . adrenaline and noradrenaline.

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