Zwitterionic molecularly imprinted polymer‐based solid‐phase micro‐extraction coupled with molecularly imprinted polymer sensor for ultra‐trace sensing of  L ‐histidine | Zendy

Prasad Bhim Bali | Zendy; Tiwari Khushaboo | Zendy; Singh Meenakshi | Zendy; Sharma Piyush S. | Zendy; Patel Amit K. | Zendy; Srivastava Shrinkhala | Zendy

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Zwitterionic molecularly imprinted polymer‐based solid‐phase micro‐extraction coupled with molecularly imprinted polymer sensor for ultra‐trace sensing of L ‐histidine

Author(s) -

Prasad Bhim Bali,

Tiwari Khushaboo,

Singh Meenakshi,

Sharma Piyush S.,

Patel Amit K.,

Srivastava Shrinkhala

Publication year - 2009

Publication title -

journal of separation science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.72

H-Index - 102

eISSN - 1615-9314

pISSN - 1615-9306

DOI - 10.1002/jssc.200800595

Subject(s) - molecularly imprinted polymer , detection limit , solid phase extraction , analyte , polymer , chromatography , chemistry , solid phase microextraction , extraction (chemistry) , sorption , molecular imprinting , adsorption , selectivity , mass spectrometry , gas chromatography–mass spectrometry , organic chemistry , catalysis

The proposed L ‐histidine sensing system composed of a molecularly imprinted solid‐phase microextraction component combined with a molecularly imprinted polymer sensor was used to determine critical levels of test analyte in a complex matrix of highly diluted human blood serum without any non‐specific sorption and false‐positive contributions. The molecularly imprinted polymer was a zwitterionic polymer brush derived from the disodium salt of EDTA and chloranil, grafted to solid‐phase microextraction material. The hyphenated approach was able to detect L ‐histidine quantitatively with a limit of detection as low as 0.0435 ng/mL ( RSD = 0.2%, S/N = 3).

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