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Statistical mixture design investigation of fractionated and total extracts from Erythrina speciosa Andrews leaves
Author(s) -
Soares Patricia Kaori,
Bruns Roy Edward,
Scarminio Ieda Spacino
Publication year - 2009
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200800534
Subject(s) - erythrina , chromatography , statistical analysis , chemistry , mathematics , botany , biology , statistics
The simplex centroid mixture design for the ethanol, dichloromethane, hexane and acetone solvents has been applied to the extraction of crude mass and the fiber, organic, neutral and basic fractions as well as the fractionation residues of Erythrina speciosa Andrews leaves. Binary and ternary synergic solvent interactions are seen to provide dominant contributions to the extraction of both crude mass and all the fractions. Quadratic and special cubic mixture models precisely predict the extracted quantities of each fraction and the residue as a function of the proportions of the four solvents. Different solvent mixtures are found to be the most efficient extractors for the different fractions: binary dichloromethane‐hexane mixtures for the fiber fraction, ternary ethanol‐dichloromethane‐acetone mixtures for the neutral fraction, binary ethanol‐dichloromethane mixtures for the organic fraction, crude extract and residue values and ternary ethanol‐dichloromethane‐hexane mixtures for the basic fraction. Principal component analysis shows that the ethanol‐dichloromethane mixtures are important for extracting large quantities of the basic and organic fractions as well as of the residue and crude masses.