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Cyclodextrin‐modified MEKC for enantioseparation of hexaconazole, penconazole, and myclobutanil
Author(s) -
Wan Ibrahim Wan Aini,
Hermawan Dadan,
Sanagi M. Marsin,
AboulEnein Hassan Y.
Publication year - 2009
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200800512
Subject(s) - myclobutanil , hexaconazole , chemistry , enantiomer , triazole , micellar electrokinetic chromatography , chromatography , cyclodextrin , fungicide , stereochemistry , capillary electrophoresis , organic chemistry , botany , biology , carbendazim
Abstract A CD‐modified micellar EKC (CD‐MEKC) method with 2‐hydroxypropyl‐γ‐CD (HP‐γ‐CD) as chiral selector for the enantioseparation of three chiral triazole fungicides, namely hexaconazole, penconazole, and myclobutanil, is reported for the first time. Simultaneous enantioseparation of the three triazole fungicides was successfully achieved using a CD‐MEKC system containing 40 mM HP‐γ‐CD and 50 mM SDS in 25 mM phosphate buffer (pH 3.0) solution with resolutions ( R s ) greater than 1.60, peak efficiencies ( N ) greater than 200 000 for all enantiomers and an analysis time within 15 min compared to 36 min as previously reported using sulfated‐β‐CD.