Premium
Enantioselective separation of chiral vicinal diols in capillary electrophoresis using a mono‐6 A ‐aminoethylamino‐β‐cyclodextrin as a chiral selector
Author(s) -
Liu Peng,
Sun Xiaoli,
He Wei,
Jiang Ru,
Wang Pingan,
Zhao Yan,
Zhang Shengyong
Publication year - 2009
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200800423
Subject(s) - enantioselective synthesis , capillary electrophoresis , vicinal , chemistry , enantiomer , cyclodextrin , selectivity , resolution (logic) , chiral resolution , cationic polymerization , chromatography , dihydroxylation , enantiomeric excess , catalysis , organic chemistry , artificial intelligence , computer science
This paper describes an improved access to mono‐6 A ‐aminoethylamino‐β‐CD (β‐CDen), a very efficient cationic chiral selector for CZE in the separation of eight chiral aromatic vicinal diols. The β‐CDen concentration has a strong influence on the efficiency of enantioseparation. The effects of the pH and concentration of the BGE, the capillary temperature, and the applied voltage on the resolution and separation selectivity have been studied. Excellent chiral resolution was achieved under the optimal conditions of β‐CDen 10 mM, pH 10, 200 mM borate buffer at 15 kV and 20°C within 20 min. Moreover, the developed method was successfully applied to the determination of the enantiomeric purity of the catalytic asymmetric dihydroxylation (AD) reaction products.