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Monosubstituted positively charged cyclodextrins: Synthesis and applications in chiral separation
Author(s) -
Tang Weihua,
Ng Siu Choon
Publication year - 2008
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200800357
Subject(s) - chemistry , analyte , chiral stationary phase , chromatography , supercritical fluid chromatography , supercritical fluid , context (archaeology) , alkyl , resolution (logic) , high performance liquid chromatography , solvent , chiral derivatizing agent , cyclodextrin , chromatographic separation , chiral column chromatography , organic chemistry , paleontology , artificial intelligence , computer science , biology
Several series of novel structurally well‐defined positively charged CDs, applicable to α‐, β‐ and γ‐CDs for chiral separation using CE and chromatographic techniques have been developed. The chiral resolution capabilities of different series CDs towards amino acids and anionic analytes in CE are systematically investigated by considering all separation parameters including CD type, alkyl chain length of the cations attached to the CD rim, CD concentration, buffer pH, separation temperature and organic solvent. Typical results are demonstrated in the context. Examples of chiral separation with HPLC and supercritical fluid chromatography are first demonstrated by using coated chiral stationary phases (CSPs). Optimum CD loading content on the coated CSPs was explored in the chiral separation of neutral analytes.