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Offline LC‐GC×GC in combination with rapid‐scanning quadrupole mass spectrometry
Author(s) -
Sciarrone Danilo,
Quinto Tranchida Peter,
Costa Rosaria,
Donato Paola,
Ragonese Carla,
Dugo Paola,
Dugo Giovanni,
Mondello Luigi
Publication year - 2008
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200800293
Subject(s) - chromatography , chemistry , mass spectrometry , elution , gas chromatography–mass spectrometry , gas chromatography , fraction (chemistry) , analytical chemistry (journal) , two dimensional chromatography , sample preparation , diesel fuel , organic chemistry
The present research is focused on the offline combination of normal‐phase LC to double‐oven GC×GC‐quadrupole MS. Initially, a diesel sample was subjected to automated LC×GC in order to define the elution windows of four fractions, viz. , saturated hydrocarbons, monocyclic aromatics, dicyclic aromatics, tri‐ + tetracyclic aromatics; each fraction was collected exploiting the LC system in a further analysis and subjected to large‐volume‐injection‐GC×GC analysis using an apolar–polar column combination. The GC×GC operational conditions were tuned in relation to the specific separation requirements of each heart‐cut. The main benefits of what can be defined as offline LC‐GC×GC were: (i) the high first‐dimension LC selectivity; (ii) the injection of high sample amounts in the GC×GC system, enabling the detection and quantification of a series of low‐amount diesel constituents; (iii) improved GC×GC operational conditions for each heart‐cut with respect to direct GC×GC.