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Differentiation and quantification of xylene isomers by combining headspace solid‐phase microextraction/gas chromatography and self‐ion molecule reaction in an ion trap tandem mass spectrometry
Author(s) -
Yang ChihHao,
Khan Nadeem Ahmad,
Wu HuiFen
Publication year - 2008
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200800106
Subject(s) - chemistry , solid phase microextraction , chromatography , analytical chemistry (journal) , mass spectrometry , polydimethylsiloxane , ion trap , calibration curve , tandem mass spectrometry , selected reaction monitoring , gas chromatography–mass spectrometry , extraction (chemistry) , gas chromatography , detection limit , organic chemistry
A headspace solid‐phase microextraction (HS‐SPME) method using polydimethylsiloxane (PDMS)‐coated fiber coupling with GC/self‐ion molecule reaction (SIMR)/MS/MS (GC/SIMR/MS/MS) has been developed for the differentiation of o ‐, m ‐, and p ‐xylene isomers. The optimization parameters of this method are: extraction time 20 min, stirring rate 1200 rpm, sampling temperature 28°C, and salt concentration 5%. The LODs were found to be in the range of 3–9 ng/mL under the SIM mode of GC/MS. The RSDs were below 1% ( n = 5). The linear dynamic range of the calibration curve was from 0.05 to 10.0 μg/mL with correlation coefficient ( r 2 ) > 0.9089. The advantages of this technique are sensitive, selective, ease of operation, simple device, solvent free, and extremely little sample consumption. This technique is the first example using SIMR combined MS/MS applied in the GC/MS and it can be applied to other volatile compounds for future application.