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Enantioseparation of kavain on Chiralpak IA under normal‐phase, polar organic and reversed‐phase conditions
Author(s) -
Cirilli Roberto,
Ferretti Rosella,
Gallinella Bruno,
Bilia Anna Rita,
Vincieri Franco Francesco,
La Torre Francesco
Publication year - 2008
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200800044
Subject(s) - chemistry , chromatography , methanol , phase (matter) , polar , ethanol , high performance liquid chromatography , reversed phase chromatography , organic chemistry , physics , astronomy
First baseline HPLC enantioseparation of kavain is described. Complete enantiodiscrimination was achieved on the immobilised‐type Chiralpak IA chiral stationary phase (CSP) using pure methanol and simple methanol‐water and ethanol‐water mixtures as eluents. A water‐dependent enantioselectivity was clearly demonstrated. Performance of the Chiralpak IA CSP in polar organic and RP conditions was compared with that of five coated polysaccharide‐derived CSPs used in normal‐phase mode.