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Enrofloxacin‐imprinted monolithic columns synthesized using reversible addition‐fragmentation chain transfer polymerization
Author(s) -
Liu Huina,
Zhuang Xiaolei,
Turson Mamat,
Zhang Min,
Dong Xiangchao
Publication year - 2008
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200700602
Subject(s) - raft , chain transfer , polymerization , molecularly imprinted polymer , monolithic hplc column , materials science , polymer , radical polymerization , reversible addition−fragmentation chain transfer polymerization , monolith , selectivity , chemistry , chemical engineering , chromatography , high performance liquid chromatography , organic chemistry , catalysis , composite material , engineering
Molecularly imprinted monolithic columns for selective separation of enrofloxacin were prepared by Reversible Addition‐Fragmentation Chain Transfer (RAFT)‐mediated radical polymerization. Different ratios of initiation system were used in the synthesis. The structures of the monoliths were characterized to study the relationship between the synthetic conditions and morphology of the monolithic material. The separation performance of the monoliths was evaluated by liquid chromatography. Under optimized synthetic conditions, a monolithic molecularly imprinted polymer (MIP) with high selectivity and improved column efficiency was obtained. The research has shown that RAFT polymerization provides more adjustable conditions for making monolithic materials with different morphologies. The results also demonstrated that homogeneous macro‐pore size distribution and large specific surface area are the key factors providing good separation ability and column efficiency for MIP monolithic structures.