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Supercritical fluid chromatography‐mass spectrometry for chemical analysis
Author(s) -
Li Fangbiao,
Hsieh Yunsheng
Publication year - 2008
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200700581
Subject(s) - supercritical fluid chromatography , supercritical fluid , chemistry , mass spectrometry , chromatography , high performance liquid chromatography , resolution (logic) , organic chemistry , computer science , artificial intelligence
Chromatography with a supercritical fluid as the mobile phase was suggested more than four decades ago (Klesper, E., Corwin, A. H., Turner, D. A., J. Org. Chem . 1962, 27 , 700–701). Supercritical fluid chromatography (SFC) is basically a hybrid of GC and LC that eases the resolution of a mixture of compounds not conveniently resolved by either GC or LC. The mobile phases for SFC have low viscosities and high diffusion coefficients compared to those for HPLC and allow for high efficiency separations. SFC uses supercritical fluid as the mobile phase, polar organic solvents as the modifiers in conjunction with acidic/basic compounds as additives to run the chromatographic process like in HPLC. In many applications, SFC‐based methods are advantageous over HPLC‐based methods as a separation tool in terms of efficiency and economical impact perspectives. Today, the availability of commercial hardware and API interfaces with a mass spectrometer makes SFC even more widely applicable for chemical analysis in many research fields. This review summarizes a variety of novel SFC‐MS methods for chemical analysis that have been reported in the peer‐reviewed publications.