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Simultaneous determination of macrolides, sulfonamides, and other pharmaceuticals in water samples by solid‐phase extraction and LC‐(ESI) MS
Author(s) -
Pedrouzo Marta,
Borrull Francesc,
Marcé Rosa Maria,
Pocurull Eva
Publication year - 2008
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200700571
Subject(s) - sulfadiazine , solid phase extraction , chemistry , chromatography , sulfamethoxazole , trimethoprim , extraction (chemistry) , sewage , tap water , sample preparation , environmental chemistry , environmental science , antibiotics , environmental engineering , biochemistry
This paper describes a method for determining 11 pharmaceuticals in various water sources by SPE followed by LC‐(ESI) MS. SPE was carried out with Oasis TM HLB and the recoveries were 33–67% for 250 and 100 mL sewage water, 55–77% for 500 mL river water and 72–98% for 1 L tap water, with the exception of sulfamethoxazole and omeprazole which showed lower recoveries in all kinds of sample. The LODs in river water were of 5 ng/L for sulfadiazine, trimethoprim, sulfamethazine, sulfamethoxazole, and ranitidine and 10 ng/L for the other compounds. The highest concentrations found in river waters were for sulfamethoxazole (50 ng/L). In influent sewage waters, ranitidine was the most commonly detected compound with a maximum value of 0.24 μg/L.