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Fused‐core particle technology as an alternative to sub‐2‐μm particles to achieve high separation efficiency with low backpressure
Author(s) -
Cunliffe Jennifer M.,
Maloney Todd D.
Publication year - 2007
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200700260
Subject(s) - core (optical fiber) , particle (ecology) , analytical chemistry (journal) , particle size , chromatography , mass spectrometry , materials science , theoretical plate , instrumentation (computer programming) , porosity , chemistry , nanotechnology , composite material , oceanography , computer science , geology , operating system
Fused‐Core particles have recently been introduced as an alternative to using sub‐2‐μm particles in chromatographic separations. Fused‐Core particles are composed of a 1.7 μm solid core surrounded by a 0.5 μm porous silica layer ( d p = 2.7 μm) to reduce mass transfer and increase peak efficiency. The performance of two commercially available Fused‐Core particles (Advanced Materials Technology Halo C18 and Supelco Ascentis Express C18) was compared with sub‐2‐μm particles from Waters, Agilent, and Thermo Scientific. Although the peak efficiencies were only ∼80% of those obtained by the Waters Acquity particles, the 50% lower backpressure allowed columns to be coupled in series to increase peak efficiency to 92 750 plates. The low backpressure and high efficiencies of the Fused‐Core particles offer a viable alternative to using sub‐2‐μm particles and very‐high‐pressure LC instrumentation.