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Rapid simultaneous determination of 14 sulfonamides in wastewater by liquid chromatography tandem mass spectrometry
Author(s) -
Ye Sai,
Yao Ziwei,
Na Guangshui,
Wang Juying,
Ma Deyi
Publication year - 2007
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200600539
Subject(s) - chromatography , chemistry , wastewater , formic acid , liquid chromatography–mass spectrometry , effluent , tandem mass spectrometry , mass spectrometry , methanol , sulfadimidine , analyte , organic chemistry , waste management , engineering
This paper describes a rapid method for the determination of 14 kinds of sulfonamides (SAs) in wastewater using SPE, and LC‐MS/MS with positive ESI (ESI(+)) and selected reaction monitoring (SRM) mode. The SPE was performed on an Oasis hydrophilic‐lipophilic‐balanced (HLB) cartridge. Chromatographic separation on a C18 column was achieved using a binary eluent containing methanol and water with 0.2% formic acid. Typical recoveries of the analytes ranged from 22.3 to 87.0% at a fortification level of 100 ng/L. The LODs in wastewater except sulfathiazole (3 ng/L) could be detected and quantified at levels as low as 1 ng/L. Finally, the method was applied to water from the municipal outlet and the aquaculture wastewater effluent. Sulfamethazine (SM 2 ), sulfamethoxypyridazine (SMP), and sulfamethoxazole (SMZ) were most frequently found in wastewater in a concentration range between 1.2 and 31.7 ng/L.