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Practice and theory of high temperature liquid chromatography
Author(s) -
McNeff Clayton V.,
Yan Bingwen,
Stoll Dwight R.,
Henry Richard A.
Publication year - 2007
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200600526
Subject(s) - chromatography , high performance liquid chromatography , chemistry
High temperature liquid chromatography (HTLC) exists in a temperature region beyond ambient ( ca. 40°C) and below super critical temperatures. The promises of HTLC, such as increased analysis speed, enhanced separation productivity, “green” LC with pure water mobile phases coupled to universal FID detection, and fast analysis of complex samples by combination with fast 2‐D techniques, have become an option for routine practice. The focus of this paper is to review the key developments that have made the application of HTLC a practical technique and draw attention to new developments in 2‐D techniques that incorporate HTLC that offer an opportunity to vastly increase the usefulness of HPLC for the analysis of complex samples.