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Automated screening platform with isochronal‐parallel analysis and conditioning for rapid method development of chiral separations
Author(s) -
Wetli Herbert A.,
Francotte Eric
Publication year - 2007
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200600491
Subject(s) - chromatography , column (typography) , high performance liquid chromatography , separation (statistics) , chemistry , process engineering , set (abstract data type) , computer science , analytical chemistry (journal) , engineering , machine learning , telecommunications , frame (networking) , programming language
An automated chiral separation‐screening platform was developed, allowing separation analysis on one column while another column is simultaneously equilibrated with a different mobile phase (MP). The platform can be set up from usual HPLC components at moderate cost and it considerably speeds up the screening process, allowing numerous chromatographic conditions to be tested within a short period of time and leading to a significant gain in time and productivity in preparative separations.