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(S)‐(–)‐α,α‐Di(2‐naphthyl)‐2‐pyrrolidinemethanol, a useful tool to study the recognition mechanism in chiral ligand‐exchange chromatography
Author(s) -
Natalini Benedetto,
Sardella Roccaldo,
Macchiarulo Antonio,
Natalini Serena,
Pellicciari Roberto
Publication year - 2007
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200600242
Subject(s) - chemistry , chiral derivatizing agent , chiral stationary phase , mechanism (biology) , ligand (biochemistry) , chiral column chromatography , chromatography , stereochemistry , combinatorial chemistry , high performance liquid chromatography , receptor , philosophy , biochemistry , epistemology
A dynamic coating of the RP‐18 carbon chain layers with the new chiral selector ( S )‐(–)‐α,α‐di(2‐naphthyl)‐2‐pyrrolidinemethanol allowed the formation of a mixed chiral stationary phase that has been used in the separation of a selected set of amino acid racemates. Both a representative model and classification structure‐property relationship studies have been performed in order to study the contribution of hydrophobic, bulky and electron‐donating groups in the side chain of the chiral selector to the mechanism of chiral recognition.