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Comparison of monolithic approaches for enantioselective capillary electrochromatography involving cyclodextrins
Author(s) -
Wistuba Dorothee,
Schurig Volker
Publication year - 2006
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200600114
Subject(s) - capillary electrochromatography , enantioselective synthesis , electrochromatography , chemistry , chromatography , capillary electrophoresis , capillary action , materials science , organic chemistry , catalysis , composite material
The access to CD‐modified monoliths for enantiomeric separation by CEC can be divided into two main approaches. (i) Silica‐based monoliths, prepared by either a sol–gel process or by sintering of silica particles, are modified after fabrication by coating with a CD selector. Alternatively the fusion of CD functionalized silica particle via gluing is feasible. (ii) Rigid or homogeneous organic polymer‐based monoliths, prepared by polymerization of organic monomers in the presence of a porogen, are modified with the CD selector either by copolymerization or by physical incorporation into the continuous bed.